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pentobarbital will reduce the extent or effect of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with robust CYP3A4 inducers isn't recommendedMonitor Carefully (2)pentobarbital will minimize the extent or effect of buprenorphine, long-acting injection by impacting hepatic/intestinal enzyme CY